Buy Cernos Gel 5gm Online

• Brand: Generic AndroGel
• Composition: Testosterone (1% w/w)
• ATX: G03BA03 Testosterone
• Pharmacotherapeutic group: Androgen
• Treatment: Low Male Testosterone Level
• Packaging Size: 1 x 14 sachets
• Manufacturer: Sun Pharmaceutical Industries Ltd.

Description

Indications:

Testosterone replacement therapy for hypogonadism in men, when testosterone deficiency is confirmed by clinical symptoms and laboratory tests.

Active substance:

Testosterone 50 mg

Excipients: isopropyl myristate 25 mg, carbomer 980 45 mg, sodium hydroxide 236 mg, ethanol 96% 3.570 g, purified water up to 5 g.

In 1 extractable dose of a vial containing 1.25 g of gel:

Active substance:

• Testosterone 12.5 mg

Excipients: isopropyl myristate 6.25 mg, carbomer 980 11.25 mg, sodium hydroxide 59 mg, ethanol 96% 0.892 g, purified water up to 1.25 g.

A transparent or slightly opalescent colorless gel with a characteristic alcohol odor.

Pharmacodynamics:

Endogenous androgens, mainly testosterone secreted by the testicles, and their main metabolite dihydrotestosterone are responsible for the development of external and internal genitalia and for the development and preservation of secondary sexual characteristics (stimulating hair growth, coarsening voice), libido; for the overall effect on protein anabolism; for the development of skeletal muscles and the distribution of subcutaneous fat; for reduction of urinary excretion of nitrogen, sodium, potassium, chlorides, phosphates and water.

Testosterone does not cause the development of testicles: it reduces the pituitary secretion of gonadotropins.

The effects of testosterone on some target organs are manifested after the peripheral conversion of testosterone into estradiol, which then binds to estrogen receptors in the nuclei of target organ cells (such as the pituitary gland, adipose tissue, brain, bones, etc.).

Pharmacokinetics:

Suction

The degree of absorption of testosterone through the skin varies from about 9% to 14% of the applied dose. After absorption through the skin, testosterone enters the systemic circulation in relatively constant concentrations for 24 hours.

Distribution

The concentration of testosterone in the blood plasma increases from the first hour after the use of Cernos Gel, reaching a constant value from the 2nd day of therapy. The daily fluctuations in testosterone concentrations have the same amplitude as the changes in endogenous testosterone concentration observed in circadian rhythms. With the external route of administration of the drug, there are no supraphysiological peaks in the concentration of testosterone in the blood that occur with the injection method of use.

In contrast to oral androgen therapy, external use of the drug does not cause an increase in concentrations of sex hormones in the liver above physiological norms.

The use of 5 g of Cernos Gel causes an average increase in the concentration of testosterone in blood plasma by approximately 2.5 ng / ml (8.7 nmol/l).

After discontinuation of treatment, testosterone concentration begins to decrease approximately 24 hours after the last dose. The concentration returns to its initial level approximately 72-96 hours after taking the last dose.

Metabolism

The main active metabolites of testosterone are dihydrotestosterone and estradiol.

Withdrawal

Cernos Gel is mainly excreted by the kidneys and through the intestines in the form of conjugated testosterone metabolites.

Dosage

The recommended dose is 5 g of gel (i.e. 50 mg of testosterone), applied once a day at about the same time, preferably in the morning.

The individual daily dose can be adjusted by the doctor depending on the clinical and laboratory parameters in patients, but should not exceed 10 g of gel per day. Testosterone dose adjustment should be carried out in stages of 2.5 g of gel per day.

A constant concentration of testosterone in the blood plasma is achieved approximately on the 2nd day of use of Cernos Gel. To correct the dose of Cernos Gel, it is necessary to determine the concentration of testosterone in the blood plasma in the morning, before applying the gel to the skin, from the 3rd day after the start of treatment (within one week).

The dose of the drug can be reduced with an increase in the concentration of testosterone in the blood plasma. With a decrease in the concentration of testosterone in the blood plasma, the dose of Cernos Gel can be increased, but not more than 10 g of gel per day.

Using

It is applied transdermally

The gel is applied by the patient himself to clean, dry, undamaged skin of the shoulder, forearms or abdomen. Do not apply the gel to the area of the external genitals, as the high content of ethyl alcohol in the preparation can cause local irritation.

• After removing the Cernos Gel from the bag into the palm of your hand, you should immediately apply it to the skin.
• The Cernos Gel is applied carefully in a thin layer.
• No need to rub the Cernos Gel into the skin.
• The Cernos Gel should be allowed to dry for 3-5 minutes.
• After applying the Cernos Gel to the skin, wash your hands with soap.

Stable testosterone concentration is achieved approximately on the 2nd day of Cernos Gell treatment. To adjust the dose of testosterone, it is necessary to determine the concentration of testosterone in the serum in the morning, before using the drug, from the third day after the start of treatment (within one week). The dosage can be reduced if the testosterone content in the plasma exceeds the target value. If the concentration is low, the dose can be increased, but not more than 10 g per day.

Side effects

Very often

• local reactions: erythema, acne, dry skin

Often

• polycythemia, increased lipid levels
• changes in the state of the prostate gland
• gynecomastia, mastodynia
• headache, dizziness
• paresthesia, amnesia, hyperesthesia
• mood change
• increased blood pressure
• diarrhea
• alopecia, urticaria
• aggression, irritability