Buy Generic Zydena® 100 MG Online
- Brand: Zydena® Tablet
- Composition: Udenafil
- Power: 100mg
- Treatment: Treatment of erectile dysfunction characterized by the inability to achieve or maintain an erection of the penis sufficient for satisfactory sexual intercourse.
- Take: 40-60 minutes before sexual intercourse
- Effect of the drug: up to 12-24 hours
- Daily dosage: no more than 1 tablet per day
- Manufacturer: Sunrise Remedies Pvt. Ltd.
- Country of Origin: India
Zydena® 100 MG Udenafil Tablets for Sale Online
Zydena® 100 MG tablets are a 24-hour readiness for sex and an increased level of safety of a drug for erectile dysfunction.
- The duration of action is up to 24 hours.
- High quality sex.
- It can be used with alcohol.
- Increased profile of cardiovascular safety.
- Does not affect pressure, does not change color perception.
- Highly selective action.
- The original drug has no analogues.
How does Zydena® 100 MG tablets work?
Erectile Dysfunction (ED) is a common disease in adult men and refers to a condition in which an erection is not achieved or maintained sufficiently for satisfactory sexual activity. A man’s erection is regulated by the blood flow in the cavernous bodies, which are like a sponge.
When the smooth muscles of the vessels of the cavernous body relax and the blood flow increases, an erection is induced, and when the blood flow decreases, the erection disappears. In order for the penis to be in a state of erection, nitric oxide (NO) is needed, a powerful vasodilating agent secreted by the end of the parasympathetic nervous system, blood vessels or endothelial cells of the cavernous bodies, which is produced in smooth muscles through the synthesis of a substance called cGMP (cyclic guanosine monophosphate) in the cytoplasm, which causes and maintains an erection, relaxing her. cGMP is hydrolyzed by phosphodiesterase type 5 (PDE5), an enzyme specific to cGMP. The substance that inhibits this enzyme is a PDE5 inhibitor, which prevents the destruction of cGMP and helps maintain an erection.
Zydena® 100 MG Udenafil Tablets are an inhibitor of PDE-5 activity for the treatment of erectile dysfunction and are a drug that helps men maintain an erection.
Overview of Zydena® 100 MG Tablets
Zydena® 100 MG – tablets for the treatment of erectile dysfunction. Phosphodiesterase inhibitor-type 5. Udenafil is a selective reversible inhibitor of cyclic guanosine monophosphate (cGMP) – specific phosphodiesterase type 5 (PDE-5).
Udenafil does not have a direct relaxing effect on the isolated cavernous body, but during sexual stimulation enhances the relaxing effect of nitric oxide by inhibiting PDE-5, responsible for the breakdown of cGMP in the cavernous body. The consequence of this is relaxation of the smooth muscles of the arteries and blood flow to the tissues of the penis, which causes an erection. The drug has no effect in the absence of sexual stimulation.
In vitro studies have shown that udenafil is a selective inhibitor of the enzyme PDE-5. PDE-5 is present in the smooth muscles of the cavernous body, in the smooth muscles of the vessels of internal organs, in skeletal muscles, platelets, kidneys, lungs and cerebellum. Udenafil is 10,000 times more potent inhibitor against PDE-5 than against PDE-1, PDE-2, PDE-3 and PDE-4, which are localized in the heart, brain, blood vessels, liver and other organs. In addition, udenafil is 700 times more active against PDE-5 than against PDE-6, found in the retina and responsible for color perception. Udenafil does not inhibit PDE-11, which causes the absence of cases of myalgia, lower back pain and manifestations of testicular toxicity.
Udenafil improves erection and the possibility of successful sexual intercourse. The effect of the drug has an optimal duration of up to 24 hours. The effect manifests itself within 30 minutes after taking the drug in the presence of sexual arousal.
Udenafil in healthy individuals does not cause significant changes in systolic and diastolic pressure in comparison with placebo in the supine and standing positions (the average maximum decrease is 1.6/0.8 mmHg and 0.2/4.6 mmHg, respectively).
Udenafil does not cause changes in color recognition (blue/green), which it is explained by its low affinity with PDE-6. Udenafil does not affect visual acuity, electroretinogram, intraocular pressure and pupil size.
In the study of udenafil in men, there was no clinically significant effect of the drug on the amount and concentration of sperm, motility and morphology of spermatozoa.
How to take Zydena ® 100 MG tablets?
- The drug Zydena® 100 MG is taken orally, regardless of food intake. The recommended dose of the drug is 100 mg, taken 30 minutes before the intended sexual activity.
- The dose can be reduced to 50 mg or increased to 200 mg, taking into account the individual effectiveness and tolerability of the drug.
- The maximum recommended frequency of use of Zydena® 100 MG tablets is once a day.
New ED Drug Zydena® 100 MG Udenafil Tablets
Dong-A Pharmaceutical (now Dong-A ST) invested about 20 billion won over 8 years to develop Zydena® 100 MG, the first oral treatment for erectile dysfunction in Korea and the fourth in the world in 2005.
Compared to the existing first-generation oral erectile dysfunction treatment with the same mechanism, it showed a strong erection-inducing effect, but the frequency of side effects such as headache, burning of the face, upset stomach, rhinitis and visual impairment was low. In particular, it selectively inhibits only PDE5 and has no inhibitory effect on PDE11 (selectivity is more than 3000 times higher), so there are no concerns about side effects such as muscle pain, back pain or testicular toxicity, and it is a drug that significantly improves the side effects of existing drugs.
It is also a second-generation oral treatment for erectile dysfunction, which has greatly contributed to the improvement of public health by demonstrating an ideal duration of effectiveness suitable for the daily rhythm of life, and reducing drug prices through the development of the process.
Zydena® 100 MG Reviews
Zydena® 100 MG is a prototype of other well–known drugs for the treatment of sexual impotence in men, such as: Cialis; Viagra; Levitra and others.
However, judging by the reviews on the Internet, despite a similar action, many note that Zydena® 100 MG is a more effective remedy, and side effects, unlike analogues, are minimized.
The effect of Zydena® 100 MG tablets should manifest itself during sexual stimulation, if there is no such thing, then changes in the tissues will not follow. The effect according to the instructions lasts a day. With sexual arousal, a man should have a stable erection about half an hour after taking the pills.
Zydena® 100 MG is good because it does not cause muscle pain, does not affect color perception, does not provoke pressure changes in healthy men.
According to reviews and characteristics, the effect of taking Zydena® 100 MG tablets is as follows:
- the return of sexual power;
- prolonging an erection;
- improving potency;
- treatment of disorders of sexual function in men resulting from physiological,
- psychological and other injuries.
There are a lot of opinions about the effectiveness of drugs and the features of its use on the Internet. In most cases, the reviews come down to the fact that men use these pills as an auxiliary that improves their sex life.
- What I like about Zydena® 100 MG is that it has much fewer side effects than other similar remedies, and they are not as pronounced as, for example, in the same Viagra. In general, these pills, as for me, are much better than the most well-known and advertised means. Zydena® 100 MG is a salvation for men who constantly face stresses that negatively affect sexual desire.
- Although I am still relatively young (I am just over 30 years old), I sometimes also use similar drugs. I used to take Cialis, but the last time it was not in the pharmacy, and they recommended Zydena® 100 MG to me. Immediately after taking the action, I did not feel it, but a few hours later the effect appeared in all its glory. It was noticeable even in the morning, despite the fact that according to the instructions it was supposed to end. Unlike Cialis, headaches and other pains did not bother him.
- Zydena® 100 MG tried for the first time. What can be noted immediately – the process has become longer and more confident, the absence of side effects. But I didn’t like Levitra – my blood pressure rose and I felt unwell right during the act. This was not observed with Zydena® 100 MG.
Contraindications Zydena® 100 MG:
- intolerance to any of the elements of the drug;
- combined use with nitrates and other nitric oxide suppliers;
- age of 18.
Caution is required when prescribing Zydena® 100 MG in such cases:
- men with uncontrolled increase in blood pressure (more than 170/100 mm Hg.ct), as well as a decrease in blood pressure (less than 90/50 mm Hg.art.);
- people with a hereditary form of degenerative retinal pathologies (among them retinitis pigmentosa, as well as proliferative DRP);
- persons who have suffered a myocardial infarction, stroke or coronary bypass surgery during the last six months;
- if the patient has kidney or liver insufficiency in severe form;
- with congenital UIQT syndrome or an elongation of this indicator due to the use of medications;
- predisposition to the development of priapism;
- men with anatomically deformed penis;
- patients with an implant in the penis;
- people with CCC pathologies – an unstable form of angina pectoris or with angina pectoris that appears during sexual contact; a chronic form of heart failure (II–IV functional class according to the NYHA classification), which has developed in the patient over the past six months; and in addition with uncontrolled heart rhythm disorders: in such cases, it is necessary to take into account the possibility of the appearance of complications;
- combined intake with alpha-blockers, BCC or other antihypertensive drugs, as this can cause an additional decrease in dBP, as well as SAD by 7-8 mmHg.
Side effects of Zydena® 100 MG
Due to the use of Zydena® 100 MG, the development of such side effects is possible:
- organs of the cardiovascular system: often there is a rush of blood to the skin of the face;
- organs of the central nervous system: in some cases, dizziness appears, paresthesia or cervical sciatica develops;
- visual organs: redness of the eyes is often observed, in more rare cases there are pains, blurred vision or increased lacrimation;
- skin: in some cases, urticaria develops, swelling occurs on the face or eyelids;
organs of the digestive system: mainly discomfort in the abdomen or dyspeptic phenomena develop; less often there are toothaches or nausea, gastritis or constipation develops;
- respiratory organs: nasal congestion usually occurs, and occasionally dyspnea or dryness of the nasal mucosa develops;
- organs of the musculoskeletal system: periarthritis develops sporadically;
- general: often there is an uncomfortable feeling in the sternum or a headache, and in addition a fever; abdominal pain, pain in the sternum, a feeling of thirst or fatigue occur occasionally.
Interaction of Zydena® 100 MG:
Inhibitors of cytochrome P450 CYP3A4 isoenzymes (ketoconazole, itraconazole, ritonavir, indinavir, cimetidine, erythromycin, grapefruit juice) may enhance the effect of Zydena® 100 MG.
Ketoconazole (at a dose of 400 mg) increases the bioavailability and Cmax of udenafil (at a dose of 100 mg) almost twice (212%) and 0.8 times (85%), respectively. Ritonavir and indinavir significantly enhance the effect of Zydena® 100 MG Udenafil.
Dexamethasone, rifampin and anticonvulsive drugs (carbamazepine, phenytoin and phenobarbital) they can accelerate the metabolism of udenafil, therefore, co-administration with the above drugs weakens the effect of Zydena® 100 MG.
The combined administration of udenafil (30 mg / kg, orally) and nitroglycerin (2.5 mg / kg once intravenously) did not show any effect on the pharmacokinetics of udenafil in experimental studies, however, the simultaneous use of nitroglycerin and udenafil is not recommended due to a possible decrease in blood pressure.
Zydena® 100 MG Udenafil and drugs from the alpha-blocker group are vasodilators, therefore, when taken together, they should be prescribed in minimal doses.
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